Discover the Top NPOs in South Africa Today

Are you passionate about making a difference in your community? Join the growing list of Non-Profit Organizations (NPOs) in South Africa that are dedicated to creating a better future for all. From education and health to animal welfare and environmental conservation, our list includes a wide range of NPOs across various causes and regions of the country.

The Power of Giving

When it comes to supporting good causes, you want to make sure that your money goes to the right charities in South Africa. There are hundreds of thousands of good charities to support in South Africa right now, and your donations will be greatly appreciated regardless of the benefactor.

Top Charity Organizations in South Africa

Here are some of the top NPOs in South Africa that are making a significant impact:

Nkosi’s Haven

This organization supports HIV-infected mothers and their children along with any AIDS orphans too. All donations raise awareness of the issue and provide assistance and education to communities affected.

Endangered Wildlife Trust

One of South Africa’s most reputable conservation NGOs, the Endangered Wildlife Trust is dedicated to preserving and protecting threatened species and ecosystems in Southern and Eastern Africa.

Breadline Africa

Breadline Africa supports childhood development by providing initiatives and infrastructure in South Africa via early education.

Operation Hunger

Operation Hunger uses donations to create food and sanitary parcels to deliver to those who need it the most in vulnerable communities. They work with local sources to verify the parcels are going to the right people.


Cansa provides help and support to those who have been affected by cancer by offering counseling, screenings, advice, research, and more. There is plenty of advice on their website for those living with cancer or regaining their life once treatment has finished.


The South African Federation for Mental Health provides support and facilities for people who need it while bringing awareness via multiple methods, including education, training, and more.

ACT Africa

ACT Africa helps to bring awareness and education of child trafficking and provides practical safety tips for vulnerable children in communities, orphanages, and care homes across South Africa.


The PDSA has a long history of helping sick and injured animals who might not otherwise receive treatment due to the high cost of veterinary care. The PDSA is a nonprofit organization.

Baby Box

Baby Box provides a reusable bag of essential items for mothers of new babies born in Johannesburg hospitals living in desperate poverty. The aim is to give new moms the support they need when they need it the most to reduce the number of child abandonment.

Protect Dignity

Protect Dignity provides sanitary products and support for young girls of menstruating age who might otherwise face gaps in their education due to missing school through lack of menstruation products. They help girls aged 10-19 and work with educators to bring awareness to the issue and provide face to face education and menstruation products.


Many charitable organizations in South Africa are worthy of your support and assistance, whether financial or practical. At NPO South Africa, we keep an updated list of registered NPOs in the country. Whether you are looking to donate or volunteer, our list provides an easy reference guide to help you find the right organization for you. So why wait? Check out our list today and start making a difference in South Africa!

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